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Proto Oncogene Products c trk

《英文msh詞典》Proto Oncogene Products c trk
[入口詞] Proto Oncogene Products c trk
[主題詞] Receptor,trkA
[英文釋義] A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4,neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with congenital insensitivity to pain with anhidrosis,while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.